Stemcell/Anti-Human CD45RA Antibody, Clone HI100/100 u00b5g/100-0321
商品编号：
100-0321
品牌：
StemCells Inc
市场价：
¥0.00
美元价：
0.00
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Overview
The HI100 antibody reacts with an extracellular epitope on the CD45RA isoform of CD45, a type I transmembrane glycoprotein and member of the protein tyrosine phosphatase family (receptor class 1/6 subfamily). Alternative splicing of exons 4, 5, and 6 that encode the extracellular RA, RB, and RC polypeptides of CD45 gives rise to several isoforms with molecular masses of 180 - 240 kDa. Excision of exon 4 generates the ~220-kDa CD45RA isoform, which is expressed on naïve T cells, subsets of B cells and monocytes, and medullary thymocytes. CD45RA functions to enhance signaling through both the T cell receptor and B cell receptor. The HI100 antibody is commonly used in combination with antibodies against the CD45RO isoform to discern naïve and memory T cells and is useful for identifying the suppressor/inducer subset of CD4+ lymphocytes. The proportion of CD45RA+ T cells typically decreases with age.
Subtype:
Primary Antibodies
Target Antigen:
CD45RA
Alternative Names:
B220, CD45, GP180, Lyt-4, Ly-5, LY5, L-CA, LCA, Protein tyrosine phosphatase receptor type C, PTPRC, T200
Reactive Species:
Chimpanzee; Human
Conjugation:
APC-Cyanine7; Biotin; PE; Unconjugated
Host Species:
Mouse
Cell Type:
Granulocytes and Subsets; Hematopoietic Stem and Progenitor Cells; Leukocytes; Lymphocytes
Application:
CyTOF; ELISA; FACS; Flow Cytometry; Functional Assay; Immunoaffinity Chromatography; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Radioimmunoassay; Western Blotting
Area of Interest:
Immunology
Clone:
HI100
Gene ID:
5788
Isotype:
IgG2b, kappa
品牌介绍
STEMCELL Technologies 成立于 1993 年，是加拿大最大的生物科技公司，为生命科学研究领域提供专业的细胞培养基和细胞分选产品。 我们的使命是为科学的不断进步提供高品质、创新的试剂、工具和服务，本着 Scientists Helping Scientists 的精神，用我们的服务帮助您的科学研究。 STEMCELL Technologies 为全球 70 多个国家提供超过 3000 种分子生物学工具，以支持干细胞、免疫学、癌症、类器官、基因编辑、细胞治疗和再生医学等领域的科学研究。我们的 mTeSR1™、MethoCult™ 和 EasySep™ 已经成为多能干细胞培养、造血干细胞鉴定以及无柱细胞分选的金标准；许多工具为广大的科研实验室所熟知。 此外，我们研发了一系列针对不同类器官的培养基，包括肠道类器官、脑类器官、肝类器官、胰类器官、上呼吸道类器官等，身体力行地推动类器官研究领域的发展。 STEMCELL Technologies，源于科研，归于科研。与您在科学的道路上携手前行！* 欲了解您区域的代理商信息，请通过电话 400-885-9050 或者邮箱 info.cn@stemcell.com 与我们联系。
