Stemcell/Anti-Human CD3 Antibody, Clone OKT3/Purified/100-0287
商品编号:
100-0287
品牌:
StemCells Inc
市场价:
¥0.00
美元价:
0.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Overview
The OKT3 antibody reacts with an extracellular conformational epitope on the ~20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. CD3 is a dimer assembled from combinations of CD3γ, δ, ε, η, and ζ subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. CD3 associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating T cell activation and the expression of the TCR on the cell surface. Mutations in CD3 have been associated with disorders of the immune system, including severe combined immunodeficiency(SCID). The OKT3 antibody recognizes an epitope that is expressed when the CD3ε subunit associates with either CD3γ or CD3δ, and binding of the antibody can induce T cell activation. Because of its immunosuppressive properties in vivo, the OKT3 antibody has proven useful in treating allograft rejection. Clone OKT3 is widely used for phenotyping human T cells, and it has been observed to block the binding of anti-CD3 antibody clones SK7 and UCHT1.
Subtype:
Primary Antibodies
Target Antigen:
CD3
Alternative Names:
CD3 epsilon, CD3ε, Leu-4, T3
Reactive Species:
Human
Conjugation:
APC; FITC; Unconjugated
Host Species:
Mouse
Cell Type:
T Cells
Application:
Flow Cytometry; Functional Assay; Immunohistochemistry; Western Blotting
Area of Interest:
Immunology
Clone:
OKT3
Gene ID:
916
Isotype:
IgG2a, kappa
品牌介绍
STEMCELL Technologies 成立于 1993 年,是加拿大最大的生物科技公司,为生命科学研究领域提供专业的细胞培养基和细胞分选产品。 我们的使命是为科学的不断进步提供高品质、创新的试剂、工具和服务,本着 Scientists Helping Scientists 的精神,用我们的服务帮助您的科学研究。 STEMCELL Technologies 为全球 70 多个国家提供超过 3000 种分子生物学工具,以支持干细胞、免疫学、癌症、类器官、基因编辑、细胞治疗和再生医学等领域的科学研究。我们的 mTeSR1™、MethoCult™ 和 EasySep™ 已经成为多能干细胞培养、造血干细胞鉴定以及无柱细胞分选的金标准;许多工具为广大的科研实验室所熟知。 此外,我们研发了一系列针对不同类器官的培养基,包括肠道类器官、脑类器官、肝类器官、胰类器官、上呼吸道类器官等,身体力行地推动类器官研究领域的发展。 STEMCELL Technologies,源于科研,归于科研。与您在科学的道路上携手前行!* 欲了解您区域的代理商信息,请通过电话 400-885-9050 或者邮箱 info.cn@stemcell.com 与我们联系。