4000-520-616
欢迎来到免疫在线!(蚂蚁淘生物旗下平台)  请登录 |  免费注册 |  询价篮
主营:主营:细胞治疗中枢神经系统和肝脏疾病的研究
咨询热线电话
4000-520-616
当前位置: 首页 > 产品中心 > peptide > 干细胞/抗小鼠MHC II类(I-A/I-E)抗体,克隆M5/114.15.2/FITC/100-0291
商品详细干细胞/抗小鼠MHC II类(I-A/I-E)抗体,克隆M5/114.15.2/FITC/100-0291
干细胞/抗小鼠MHC II类(I-A/I-E)抗体,克隆M5/114.15.2/FITC/100-0291
干细胞/抗小鼠MHC II类(I-A/I-E)抗体,克隆M5/114.15.2/FITC/100-0291
商品编号: 100-0291
品牌: StemCells Inc
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview

The M5/114.15.2 (M5/114) antibody reacts with an extracellular epitope on the mouse major histocompatibility complex class II receptor (MHC-II). MHC-II is a heterodimeric transmembrane glycoprotein comprising an α subunit associated non-covalently with a β subunit. In mice, MHC-II complexes are designated I-A and I-E and comprise Aα/Aβ and Eα/Eβ heterodimers, respectively. Together with the CD3/T cell receptor (TCR) complex and CD4 molecules, MHC-II mediates a critical function in presenting peptides generated from hydrolysis of exogenous antigens by antigen-presenting cells to CD4+ T (helper) cells, thereby either suppressing or inducing an immune response to the peptides. The M5/114.15.2 antibody recognizes a polymorphic determinant shared by the I-Ab, I-Ad, I-Aq, I-Ed, and I-Ek (but not I-Af, I-Ak, or I-As) MHC class II alloantigens expressed on B cells, dendritic cells, macrophages, monocytes, and activated T cells of mice carrying the H-2b, d, p, q, r, and u haplotypes (but not haplotypes H-2f or H-2s). The M5/114 antibody reportedly inhibits I-A-restricted responses by T cells of the H-2b, d, q, and u (but not H-2f, k, or s) haplotypes. It does not react with cells from NOD (H-2g7) mice.
Subtype:
Primary Antibodies
Target Antigen:
MHC Class II (I-A/I-E)
Alternative Names:
IA,I-A, IA/IE, I-A/E, I-E, MHC class II, MHC-II
Reactive Species:
Mouse
Conjugation:
APC; FITC; PE; Unconjugated
Host Species:
Rat
Cell Type:
B Cells; Macrophages; Monocytes; T Cells
Application:
CyTOF; Flow Cytometry; Functional Assay; Immunocytochemistry; Immunofluorescence; Immunohistochemistry; Immunoprecipitation; Radioimmunoassay; Western Blotting
Area of Interest:
Immunology
Clone:
M5/114.15.2
Gene ID:
14961/14969
Isotype:
IgG2b, kappa
品牌介绍
STEMCELL Technologies 成立于 1993 年,是加拿大最大的生物科技公司,为生命科学研究领域提供专业的细胞培养基和细胞分选产品。 我们的使命是为科学的不断进步提供高品质、创新的试剂、工具和服务,本着 Scientists Helping Scientists 的精神,用我们的服务帮助您的科学研究。 STEMCELL Technologies 为全球 70 多个国家提供超过 3000 种分子生物学工具,以支持干细胞、免疫学、癌症、类器官、基因编辑、细胞治疗和再生医学等领域的科学研究。我们的 mTeSR1™、MethoCult™ 和 EasySep™ 已经成为多能干细胞培养、造血干细胞鉴定以及无柱细胞分选的金标准;许多工具为广大的科研实验室所熟知。 此外,我们研发了一系列针对不同类器官的培养基,包括肠道类器官、脑类器官、肝类器官、胰类器官、上呼吸道类器官等,身体力行地推动类器官研究领域的发展。 STEMCELL Technologies,源于科研,归于科研。与您在科学的道路上携手前行!* 欲了解您区域的代理商信息,请通过电话 400-885-9050 或者邮箱 info.cn@stemcell.com 与我们联系。