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商品详细干细胞/人重组ACE2蛋白,aa18-740(HEK293表达)/100 u00b5g/100-0598
干细胞/人重组ACE2蛋白,aa18-740(HEK293表达)/100 u00b5g/100-0598
干细胞/人重组ACE2蛋白,aa18-740(HEK293表达)/100 u00b5g/100-0598
商品编号: 100-0598
品牌: StemCells Inc
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 多肽合成
公司分类: peptide
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Overview

Human Recombinant Angiotensin-Converting Enzyme 2 (ACE2) Protein, aa18-740, is expressed in HEK293 cells. ACE2 activity results in vasodilation by degrading vasoconstrictor angiotensin II to produce vasodilator angiotensin. Decreased expression of this enzyme is associated with cardiovascular disease and possibly also glomerular injury in diabetic nephropathy. ACE2 contains a peptidase domain at the N-terminus and a single transmembrane helix. ACE2 is also the primary human receptor for the surface spike glycoprotein of SARS-CoV-2 and SARS-CoV. This receptor is expressed in human lung and small intestine epithelia as well as the heart, kidney, and testes. The peptidase domain of ACE2 binds to the protein-binding domain of the S1 protein subunit of the spike protein; this binding results in a cleavage site becoming exposed. Cleavage, or ‘protein priming’, is done by TMPRSS2, a cellular serine protease, and by cathepsins. This cleavage activates the S2 subunit of the spike protein, allowing the fusion of the viral membrane to the host cell membrane. At the carboxy terminus, Human Recombinant ACE2 Protein contains a TEV site and a human IgG1 Fc tag.
Alternative Names:
Angiotensin-converting enzyme-related carboxypeptidase; Angiotensin-converting enzyme homolog
Species:
Human
Area of Interest:
Infectious Diseases
Molecular Weight:
112.5 kDa
Purity:
≥ 85%
品牌介绍
STEMCELL Technologies 成立于 1993 年,是加拿大最大的生物科技公司,为生命科学研究领域提供专业的细胞培养基和细胞分选产品。 我们的使命是为科学的不断进步提供高品质、创新的试剂、工具和服务,本着 Scientists Helping Scientists 的精神,用我们的服务帮助您的科学研究。 STEMCELL Technologies 为全球 70 多个国家提供超过 3000 种分子生物学工具,以支持干细胞、免疫学、癌症、类器官、基因编辑、细胞治疗和再生医学等领域的科学研究。我们的 mTeSR1™、MethoCult™ 和 EasySep™ 已经成为多能干细胞培养、造血干细胞鉴定以及无柱细胞分选的金标准;许多工具为广大的科研实验室所熟知。 此外,我们研发了一系列针对不同类器官的培养基,包括肠道类器官、脑类器官、肝类器官、胰类器官、上呼吸道类器官等,身体力行地推动类器官研究领域的发展。 STEMCELL Technologies,源于科研,归于科研。与您在科学的道路上携手前行!* 欲了解您区域的代理商信息,请通过电话 400-885-9050 或者邮箱 info.cn@stemcell.com 与我们联系。